Safety of Dorzagliatin in renal failure
- In patients with renal insufficiency, the AUC and Cₘₐₓ values did not differ clinically significantly from the group of healthy volunteers.
- There was no increase in the frequency of side effects.
- The drug is mainly excreted by the liver, and not through the kidneys.
Efficacy and effect on renal function
- In long-term therapy , no statistically significant deterioration of renal function indicators (eGFR, creatinine) was recorded.
- An international study on the effect of Dorzagliatin on the progression of nephropathy has been initiated (NCT06222476).
Practical application
For doctors
- The drug does not require dose adjustment in patients with impaired renal function, including ESRD.
- It is suitable in mono-and combination therapy, especially with drugs that do not have a negative effect on the kidneys.
- It does not provoke hypoglycemia, even in combination with metformin or DPP-4 inhibitors.
- It is well tolerated by elderly patients and people with concomitant cardiovascular pathology.
For patients
- It does not require frequent dose adjustments — this reduces anxiety and simplifies monitoring.
- It doesn’t cause sugar spikes, which means less fatigue, headaches, palpitations, and other symptoms of unstable glycemia.
- Reduces the risk of hypoglycemia-especially important for those who are afraid of nighttime sugar drops or live alone.
- Improves overall well-being: By stabilizing your metabolism, Dorzagliatin helps restore clarity, energy, and reduce anxiety.
Dorzagliatin as a choice for diabetes and kidney failure
This makes it a promising choice both for starting therapy and at stages when other drugs are no longer possible due to limitations in renal function.
For the final decision on the inclusion of Dorzagliatin in therapy, medical consultation, monitoring of glycemia and renal parameters, as well as taking into account the individual characteristics of the patient, is necessary.
Sources:
https://pmc.ncbi.nlm.nih.gov
https://www.clinicaltrials.gov
https://www.cureus.com
