Dorzagliatin is a modern hypoglycemic drug developed for the treatment of type 2 diabetes mellitus. Its uniqueness lies in the double activation of glucokinase, a key enzyme in the regulation of glucose levels. To get the maximum benefit from therapy, it is important to strictly follow the recommended dosage and intake regimen. In this article, we will look at how to take Dorzagliatin correctly, which regimens are optimal, and what to consider when treating patients with various concomitant conditions.
Recommended dosage
The optimal and clinically proven dose of Dorzagliatin is 75 mg twice daily -in the morning and in the evening. This dosage was used in large clinical trials, including phase III, and showed a steady decrease in glycated hemoglobin (HbA1c) and improved beta-cell function without increasing the risk of hypoglycemia.
The twice-a-day approach provides even stimulation of glucokinase throughout the day and night, preventing sudden spikes in glucose after meals and during the night period. This particular regimen has proven effective in combination with metformin and as monotherapy.
Medication regimen
The drug is taken twice a day -in the morning and in the evening, preferably with a meal or immediately after. It improves tolerability and provides stable pharmacokinetics. Skipping a dose reduces effectiveness, especially if Dorsagliatine is used as part of a combination therapy.
It is important to explain to patients that regular intake is the basis for stable glycemic control. It is advisable to set reminders or link appointments to your usual routine (such as breakfast and dinner) to minimize the risk of missing out.
Start of therapy and monitoring
Before starting treatment with Dorzagliatin, the doctor should conduct a complete clinical and laboratory examination: check the fasting glucose level, HbA1c, liver and kidney function (ALT, AST, eGFR), as well as clarify the presence of concomitant diseases and medications taken.
Monitoring of effectiveness is usually carried out 4-8 weeks after the start of therapy. During this time, the glucose level stabilizes and the main therapeutic effect is manifested. Regular monitoring allows you to adjust the treatment if necessary and detect undesirable reactions in time.
Dosage features for concomitant conditions
In patients with mild to moderate renal insufficiency , Dorzagliatin does not require dosage adjustment — this is an important advantage over many other hypoglycemic agents. However, in cases of severe renal or hepatic insufficiency, its use requires special caution or complete withdrawal due to insufficient safety data.
In elderly patients, especially in the presence of polypharmacy, the drug can be prescribed at a standard dose, but with mandatory monitoring of the condition and assessment of potential interactions with other drugs.
Compatibility with other drugs
Dorzagliatin combines well with metformin, DPP-4 and SGLT2 inhibitors, without requiring a change in their dosage. No pharmacokinetic conflicts were found in the studies, which makes Dorzagliatin a convenient component of combination therapy.
When prescribed together with other hypoglycemic agents, it is important to take into account the possible total effect on glucose levels. At the beginning of combined treatment, it is recommended to monitor glycemic indicators more often, especially in patients with unstable sugar.
What to do if you miss a dose
If the patient missed taking the drug, you should take it as soon as possible, but do not double the dose. If the time for the next intake is already close — it is better to skip the missed dose and return to the usual schedule.
Regular skipping may reduce the effectiveness of treatment. It is important for doctors to motivate the patient to follow the regime and, if necessary, use visual reminders, mobile applications or family assistance.
The correct Dorzagliatin regimen is not just a formality, but a key factor in its clinical effectiveness. The recommended dose is 75 mg twice a day, taken with meals or immediately after, and the effect is estimated after 4-8 weeks from the start of therapy.
However, it is important to emphasize: prescribing the drug, selecting the dosage, monitoring the effectiveness and compatibility with other drugs should be carried out exclusively under the supervision of a doctor. . This allows you to take into account the individual characteristics of the patient, avoid potential risks and ensure stable, safe control of glycemia.
Patients should follow the treatment regimen, undergo timely follow-up examinations and, if necessary, consult a specialist about any changes in their state of health or taking the drug.
Sources:
https://www.huamedicine.com
https://www.prnewswire.com
https://www.sciencedirect.com
https://clinicaltrials.gov
